NITRIC OXIDE SYNTHASE INHIBITOR SCREENIN

Code: MAK323-1KT D2-231

Features and Benefits

Compatible with high-throughput handling systems.

General description

Nitric oxide (NO) is a reactive radical that plays an...


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€448.00 EACH
€551.04 inc. VAT

Features and Benefits

Compatible with high-throughput handling systems.

General description

Nitric oxide (NO) is a reactive radical that plays an important role in many key physiological functions. NO is the oxidation product of arginine by nitric oxide synthase (NOS) and is involved in host defense development, activation of regulatory proteins and direct covalent interaction with functional biomolecules. Inhibition of NOS has the potential to produce diverse biological effects, particularly in the cardiovascular system. Simple, direct and non-radioactive procedures for measuring NOS are becoming popular in research and drug discovery.

Principle

The Nitric Oxide Synthase Inhibitor Screening Kit involves two steps: a NOS reaction step during which NO is produced followed by an NO detection step. Since the NO generated by NOS is rapidly oxidized to nitrite and nitrate, the NO production is measured following reduction of nitrate to nitrite using an improved Griess method.

Suitability

Suitable for inhibitor screening and evaluation of nitric oxide synthase inhibitors.

detection methodcolorimetric
usagesufficient for 100 colorimetric tests
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